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However, in young women this comes at a price--many women lose ovarian function because oocytes or their support cells are damaged by the treatment. A technique ensuring successful cryopreservation of oocytes would benefit women recently diagnosed with cancer who want to retain their fertility potential.

In addition, cryopreservation could help women with a family history of premature menopause as they could store their gametes before their pool of oocytes is depleted. In contrast to the success of embryo freezing, which is now a routine procedure in most in vitro fertilisation clinics, cryopreservation of oocytes has been less successful. Only a few live births after egg freezing have been achieved since the first one in Some problems have been reduced by improving cryoprotectant regimens and by using intracytoplasmic sperm injection to overcome the block to fertilisation, resulting in a few pregnancies and live births.

However, the success rate remains low--about 1 in eggs that are frozen results in a live birth. An alternative approach is cryopreservation of slices or biopsies of ovarian tissue, which contain many thousands of immature oocytes. These oocytes are quiescent and their chromatin is in a stable phase of meiosis.

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